Farnesyltransferase inhibitors in breast cancer therapy.

Abstract	Farnesyltransferase inhibitors (FTIs) belong to a group of agents originally designed to prevent membrane attachment of Ras protein by inhibiting a key step in its post-translational processing. It was thus hypothesized that FTIs would curtail the oncogenic ras-mediated proliferative and antiapoptotic signals that are activated in human tumors. Although the Ras protein is mutated in only < 5% of breast cancers, there are multiple aberrant pathways that lead to activation of wild-type ras signaling. Moreover, FTIs have consistently demonstrated efficacy in tumors regardless of their ras mutational status. Thus, the role of other protein targets in mediating the antitumor effect of FTIs is being elucidated. This article reviews current data on the use of FTIs in breast cancer.
Authors	Grace K Dy, Alex A Adjei
Journal	Cancer investigation (Cancer Invest) Vol. 20 Suppl 2 Pg. 30-7 ( 2002) ISSN: 0735-7907 [Print] England
PMID	12442347 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Enzyme Inhibitors Neoplasm Proteins Piperidines Pyridines Quinolones Deoxycytidine Capecitabine Alkyl and Aryl Transferases Farnesyltranstransferase lonafarnib tipifarnib Paclitaxel Fluorouracil
Topics	Alkyl and Aryl Transferases (antagonists & inhibitors, physiology) Animals Antineoplastic Combined Chemotherapy Protocols (therapeutic use) Breast Neoplasms (drug therapy, enzymology) Capecitabine Clinical Trials as Topic Deoxycytidine (administration & dosage, analogs & derivatives) Drug Screening Assays, Antitumor Drug Synergism Enzyme Inhibitors (pharmacology, therapeutic use) Farnesyltranstransferase Female Fluorouracil (analogs & derivatives) Humans Mice Neoplasm Proteins (antagonists & inhibitors, physiology) Paclitaxel (administration & dosage) Piperidines (administration & dosage) Protein Prenylation (drug effects) Protein Processing, Post-Translational (drug effects) Pyridines (administration & dosage) Quinolones (administration & dosage) Signal Transduction (drug effects) Tumor Cells, Cultured (drug effects) Xenograft Model Antitumor Assays

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