Linomide administration following bone marrow transplantation in mice.

Abstract

The effect of linomide, an immunomodulatory drug, on natural killer (NK) cells and T cell-dependent immune responses following syngeneic or allogeneic bone marrow transplantation (BMT) was investigated in BALB/c mice inoculated with B-cell leukemia (BCL1). Linomide given in the drinking water had no impact on graft survival or graft versus leukemia (GVL) effects. Although linomide regulates anti-self reactivity in mice with experimental and spontaneous autoimmune disorders, the anti-tumor effects induced by allogeneic donor lymphocytes were not affected. This indicates that different mechanisms regulate anti-self and anti-leukemia effects. Alternatively, linomide might affect the homing of self-reactive lymphocytes to specific target organs in autoimmune disorders, although the homing process may not be relevant to the control of leukemia by alloreactive lymphocytes.

• Authors: Lola Weiss, Ali Abdul-Hai, Yoel Shufaro, Shoshanna Reich, Shimon Slavin
• Journal: Cancer immunology, immunotherapy : CII (Cancer Immunol Immunother) Vol. 51 Issue 11-12 Pg. 596-602 (Dec 2002) ISSN: 0340-7004 [Print] Germany
• PMID: 12439604 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Hydroxyquinolines
• roquinimex

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Bone Marrow Transplantation (immunology)
• Dose-Response Relationship, Drug
• Female
• Graft vs Host Disease (etiology)
• Graft vs Leukemia Effect (drug effects)
• Hydroxyquinolines (pharmacology)
• Killer Cells, Natural (drug effects, immunology)
• Leukemia, B-Cell (prevention & control)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL