Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial.

The purpose of this study was to evaluate the effect of evening primrose oil and fish oil on breast pain in premenopausal women with severe chronic mastalgia, in a randomized double-blind factorial clinical trial.
One hundred twenty women were placed randomly into four groups: (1) fish oil and control oil, (2) evening primrose oil and control oil, (3) fish and evening primrose oils, or (4) both control oils during 6 months. Corn oil and corn oil with wheat germ oil were used as control oils. The change in the percentage of days with breast pain after 6 months of treatment was analyzed on an intention-to-treat basis.
The decrease in days with pain was 12.3 % for evening primrose oil and 13.8% for its control oil (P =.73); the decrease in days with pain was 15.5% for fish oil and 10.6% for its control oil (P =.28).
All groups showed a decrease in pain. Neither evening primrose oil nor fish oil offered clear benefit over control oils in the treatment of mastalgia.
AuthorsJacqueline Blommers, Elisabeth S m de Lange-De Klerk, Dirk J Kuik, Pieter D Bezemer, Sybren Meijer
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 187 Issue 5 Pg. 1389-94 (Nov 2002) ISSN: 0002-9378 [Print] United States
PMID12439536 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Fatty Acids, Essential
  • Fish Oils
  • Linoleic Acids
  • Plant Oils
  • Efamol
  • wheat germ oil
  • gamma-Linolenic Acid
  • Corn Oil
  • Adult
  • Breast
  • Chronic Disease
  • Corn Oil (adverse effects, therapeutic use)
  • Double-Blind Method
  • Drug Therapy, Combination
  • Fatty Acids, Essential (adverse effects, therapeutic use)
  • Female
  • Fish Oils (adverse effects, therapeutic use)
  • Humans
  • Linoleic Acids
  • Pain (drug therapy, physiopathology)
  • Pain Measurement
  • Palliative Care (standards)
  • Plant Oils (adverse effects, therapeutic use)
  • Treatment Outcome
  • gamma-Linolenic Acid

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