The treatment of psoriasis with azaribine.

Abstract

An open study was made of 25 patients with severe, recalcitrant psoriasis treated with azaribine (6-azauridine triacetate). Most patients received 125 mg/kg/day for a period of 8 weeks. A good to excellent response with 60-100% clearing of lesions was observed in 14 patients and a fair response with 40-60% improvement in another 6 patients. Thus 20 patients (80% of the series) exhibited a favorable clinical response. 16 of these 20 patients relapsed to approximately pretreatment status within 1 month after stopping therapy. The most frequently observed side-effects were mild reversible anemia, fatigue and mild transient gastrointestinal symptons. 8 patients (32% of the series) exhibited sufficient toxicity to necessitate the discontinuance of therapy. 1 patient experienced an unexplained femoral arterial thrombotic episode while on the drug. Azaribine may find a place in the therapy of severe psoriasis particularly in patients with hepatic disease. However, further studies of its potential for toxicity are indicated.

• Authors: D G Deneau, E M Farber
• Journal: Dermatologica (Dermatologica) Vol. 151 Issue 3 Pg. 158-63 ( 1975) ISSN: 0011-9075 [Print] Switzerland
• PMID: 1243822 (Publication Type: Journal Article)

Chemical References

• Azauridine

Topics

• Adolescent
• Adult
• Aged
• Azauridine (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
• Drug Evaluation
• Female
• Humans
• Male
• Middle Aged
• Psoriasis (drug therapy)