Abstract | OBJECTIVE: MATERIALS AND METHODS: Contrast-enhanced MR images of 45 patients with 85 focal nodular hyperplasia lesions were retrospectively reviewed. In these patients, sonographic findings were nonspecific (n = 37), or CT features were inconclusive (n = 8). Non-liver specific gadolinium chelates were used in 18 patients (48 lesions) suspected of having either focal nodular hyperplasia or hemangioma. The following liver-specific agents were used in patients with suspected focal nodular hyperplasia or metastases: mangafodipir trisodium, 30 patients (55 lesions); ferumoxides, six patients (16 lesions); and SHU 555 A, six patients (six lesions). Individual lesions were quantified by signal intensity and assessed qualitatively by homogeneity, contrast enhancement, and presence of a central scar. RESULTS: At unenhanced MR imaging, the triad of homogeneity, isointensity, and central scar was found in 22% of the focal nodular hyperplasia lesions. On mangafodipir trisodium-enhanced T1-weighted images, all focal nodular hyperplasia lesions showed contrast uptake: in 64% of the lesions, uptake was equal to parenchyma; 25%, greater than the parenchyma; and 11%, less than the parenchyma. On iron oxide-enhanced T2-weighted images, all focal nodular hyperplasia lesions showed uptake of the contrast agent, but contrast uptake in the lesions was less than in the surrounding parenchyma. Dynamic gadolinium chelate-enhanced MR imaging showed early and vigorous enhancement of focal nodular hyperplasia lesions with rapid washout in 88%. Atypical imaging features of the lesions included hyperintensity on T1-weighted images, necrosis and hemorrhage, and inhomogeneous or only minimal contrast uptake. CONCLUSION:
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Authors | Ahmed Ba-Ssalamah, Wolfgang Schima, Maria T Schmook, Ken F Linnau, Nadja Schibany, Thomas Helbich, Peter Reimer, Friedrich Laengle, Friedrich Wrba, Amir Kurtaran, Mark Ryan, Frederick A Mann |
Journal | AJR. American journal of roentgenology
(AJR Am J Roentgenol)
Vol. 179
Issue 6
Pg. 1447-56
(Dec 2002)
ISSN: 0361-803X [Print] United States |
PMID | 12438034
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Dextrans
- Magnetite Nanoparticles
- Oxides
- Pyridoxal Phosphate
- gadodiamide
- Edetic Acid
- Iron
- ferumoxides
- Gadolinium DTPA
- N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
- Ferrosoferric Oxide
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Topics |
- Adult
- Contrast Media
- Dextrans
- Edetic Acid
(analogs & derivatives)
- Female
- Ferrosoferric Oxide
- Focal Nodular Hyperplasia
(diagnosis)
- Gadolinium DTPA
- Humans
- Iron
- Liver
(pathology)
- Magnetic Resonance Imaging
- Magnetite Nanoparticles
- Male
- Middle Aged
- Oxides
- Pyridoxal Phosphate
(analogs & derivatives)
- Retrospective Studies
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