Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations.

Abstract

We report a case of Sezary syndrome with two abnormal CD4+ T-cell populations detected in the peripheral blood by flow cytometry immunophenotyping and DNA cell content, suggesting a biclonal T-cell lymphoproliferative disorder. Despite these findings, molecular analysis of the T-cell receptor genes was consistent with a monoclonal T-cell proliferation, supporting the existence of intraclonal diversity rather than a true biclonal disease. The patient achieved a transient response with 2-deoxycoformycin, with a selective decrease of the larger/hyperploid T-cell population; later on, an increased representation of this T-cell population was observed concomitantly with clinical relapse.

• Authors: Elisa Granjo, Margarida Lima, José Manuel Lopes, Nória Cunha, Maria Dos Anjos Teixeira, Filipe Santos, Jorge Candeias, Carlos Resende, Ana Helena Santos, Ana Balanzategui, Alberto Orfão, Estella Matutes
• Journal: British journal of haematology (Br J Haematol) Vol. 119 Issue 3 Pg. 629-33 (Dec 2002) ISSN: 0007-1048 [Print] England
• PMID: 12437636 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Pentostatin

Topics

• Aged
• Antibiotics, Antineoplastic (therapeutic use)
• CD4-Positive T-Lymphocytes (immunology)
• Cell Division
• Flow Cytometry
• Humans
• Immunophenotyping (methods)
• Male
• Pentostatin (therapeutic use)
• Phenotype
• Sezary Syndrome (drug therapy, immunology)
• Skin Neoplasms (drug therapy, immunology)
• T-Lymphocyte Subsets (immunology)