HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Intrathecal synthesis pattern of immunoglobulins in meningoencephalitis epidemic due to echovirus 9].

AbstractINTRODUCTION:
Epidemics of meningoencephalitis due to echovirus 9 were commonly occurred when a children population become susceptible for the first time in front the virus.
OBJECTIVE:
To present the intrathecal synthesis pattern of immunoglobulins of the epidemic that affected Cuba in 1999 and to probe the usefulness of reibergram and antibody index in the diagnostic and characterization of the outbreak.
PATIENTS AND METHODS:
23 pediatric patients suffering from viral meningoencephalitis due to echovirus 9 were studied in the income moment. Serum and cerebrospinal fluid IgA, IgM, IgG, albumin and glucose were quantified. Cerebrospinal fluid total protein content and lactate were quantified. Titles of antibodies against echo 9 and Coxsackie A9 and differential cell count were performed.
RESULTS:
A mean of 555 cells/10 6 L mainly lymphocytes were obtained. Glucose in cerebrospinal fluid was over 50%, serum glucose and lactate levels below 2.1 mmol/L. In the reibergram an absence of intrathecal synthesis was predominant (15/23), IgM synthesis (6/23) and IgM+IgA (2/23). Blood cerebrospinal fluid dysfunction was observed in 15 patients. The mean antibody index was 1,8 for echo 9 and 0,9 for Coxsackie A9.
CONCLUSIONS:
The intrathecal synthesis pattern of immunoglobulins was different from other enterovirus and from echovirus 9 in non epidemic situations before this epidemic, probably with alteration of viral genome.
AuthorsA J Dorta-Contreras, H Reiber, M E Magraner-Tarrau, B Weissbrich, M T Interián-Morales, E Noris-García, X Escobar-Pérez, I O González-Mujica
JournalRevista de neurologia (Rev Neurol) 2002 Nov 16-30 Vol. 35 Issue 10 Pg. 904-7 ISSN: 0210-0010 [Print] Spain
Vernacular TitlePatrones de síntesis intratecal de inmunoglobulinas en epidemia de meningoencefalitis por echovirus 9.
PMID12436393 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibodies, Viral
  • Immunoglobulins
Topics
  • Antibodies, Viral (cerebrospinal fluid)
  • Child
  • Child, Preschool
  • Cuba (epidemiology)
  • Disease Outbreaks
  • Echovirus 9 (immunology)
  • Echovirus Infections (cerebrospinal fluid, epidemiology, immunology)
  • Humans
  • Immunoglobulins (cerebrospinal fluid)
  • Meningoencephalitis (cerebrospinal fluid, epidemiology, immunology, virology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: