Motor nerve conduction velocity after carbon monoxide or m-dinitrobenzene poisoning following elimination of the poisons.

24 hrs after acute carbon monoxide or m-dinitrobenzene poisoning (about 60% CO-Hb or Met-Hb) the sciatic motor conduction velocity of rats is significantly reduced by 33% and 16% respectively. Whereas 48 hrs after methemoglobinemia the nerve conduction is normal, a retardation is detectable even 4 weeks following carboxyhemoglobinemia. Also, 4 weeks after single carbon monoxide intoxication producing a mean CO-Hb content of 19%, the motor conduction velocity is significantly decreased. This effect may be useful for detection of carbon monoxide intoxication after elimination of the poison. The results show that there are carbon monoxide effects independent of blockade of hemoglobin.
AuthorsD Pankow, W Glatzel, K Tietze, W Ponsold
JournalArchives of toxicology (Arch Toxicol) Vol. 34 Issue 4 Pg. 325-30 (Dec 18 1975) ISSN: 0340-5761 [Print] GERMANY, WEST
PMID1243627 (Publication Type: Journal Article)
Chemical References
  • Nitrobenzenes
  • Carboxyhemoglobin
  • Animals
  • Carbon Monoxide Poisoning (physiopathology)
  • Carboxyhemoglobin (analysis)
  • Male
  • Methemoglobinemia (chemically induced, physiopathology)
  • Motor Neurons (drug effects, physiology)
  • Neural Conduction (drug effects)
  • Nitrobenzenes (poisoning)
  • Rats
  • Sciatic Nerve (physiopathology)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: