Allergic bronchopulmonary aspergillosis in a lung transplant patient successfully treated with nebulized amphotericin.

Abstract

A case of allergic bronchopulmonary Aspergillosis (ABPA) complicating lung transplantation for cystic fibrosis is described. Control of ABPA was only achieved with 20 mg of prednisone and 600 mg of itraconazole per day. However, a prompt clinical and physiologic response was observed when nebulized amphotericin was introduced, which allowed prednisone to be reduced to 7.5 mg per day and, in time, all anti-fungal therapy to be withdrawn.

• Authors: Paul Casey, Jeff Garrett, Tam Eaton
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) Vol. 21 Issue 11 Pg. 1237-41 (Nov 2002) ISSN: 1053-2498 [Print] United States
• PMID: 12431500 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Glucocorticoids
• Itraconazole
• Amphotericin B
• Prednisone

Topics

• Administration, Inhalation
• Adult
• Amphotericin B (administration & dosage)
• Antifungal Agents (administration & dosage)
• Aspergillosis, Allergic Bronchopulmonary (diagnosis, drug therapy)
• Cystic Fibrosis (surgery)
• Drug Therapy, Combination
• Glucocorticoids (administration & dosage)
• Humans
• Itraconazole (administration & dosage)
• Lung Transplantation (adverse effects)
• Male
• Prednisone (administration & dosage)
• Tomography, X-Ray Computed