Primary anti-phospholipid antibody syndrome caused by isolated anti-phosphatidylethanolamine antibodies presenting as cryptogenic fibrosing alveolitis with recurrent pulmonary hemorrhage after single-lung transplantation.

Abstract

A 28-year-old man underwent a single-lung transplantation for rapidly progressive usual interstitial pneumonitis. Following transplantation, primary anti-phospholipid antibody syndrome was diagnosed after a thromboembolic event and continued dyspnea. Review of his native lung and allograft tissue showed diffuse hemorrhage secondary to capillary injury, probably reflecting anti-phospholipid antibody effects on endothelia.

• Authors: Cynthia M Magro, Amy Pope-Harman, Patrick Moh, Patrick Ross Jr
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) Vol. 21 Issue 11 Pg. 1232-6 (Nov 2002) ISSN: 1053-2498 [Print] United States
• PMID: 12431499 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies
• Phosphatidylethanolamines

Topics

• Adult
• Antibodies
• Antiphospholipid Syndrome (complications, immunology)
• Endothelium, Vascular (immunology)
• Hemorrhage (immunology, pathology)
• Humans
• Lung (blood supply, pathology)
• Lung Diseases, Interstitial (surgery)
• Lung Transplantation (immunology)
• Male
• Phosphatidylethanolamines (immunology)
• Pulmonary Fibrosis (immunology, pathology)