Abstract | AIMS: METHODS: Respective role of IL-2, IL-4, IFN-gamma, IL-10 and IL-12 in non- cancer associated AIHA were investigated by examining the spontaneous and mitogen-induced ( OKT3 or LPS) synthesis of these cytokines in PBMC cultures by ELISA methods. RESULTS: Our results affirmed that AIHA is a disease which exhibited an increased basal synthesis of IL-4 and decreased levels of IFN-gamma by AIHA PBMC compared with controls and then there is a basal increase of Th2 cytokines. Th1-type cytokine decrease in basal state occurred in parallel with an increase of constitutive IL-10 production and a IL-12 decrease. CONCLUSIONS: Decreased production of Th1-type cytokines and the production of autoantibodies in AIHA may be secondary to the imbalance between IL-10 and IL-12 and then the neutralisation of IL-10 may be efficacious in diminishing the clinical pathology associated with Th2 subset prevalence. In the same way, the treatment with IL-12 could offer a second and independent level of blockade against the consequences of the over B cell activation associated with AIHA and sometimes with cancer.
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Authors | C Toriani-Terenzi, U Pozzetto, M Bianchi, E Fagiolo |
Journal | Cancer detection and prevention
(Cancer Detect Prev)
Vol. 26
Issue 4
Pg. 292-8
( 2002)
ISSN: 0361-090X [Print] England |
PMID | 12430633
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Interleukin-10
- Interleukin-12
- Interleukin-4
- Interferon-gamma
|
Topics |
- Adolescent
- Adult
- Aged
- Anemia, Hemolytic, Autoimmune
(immunology)
- Child
- Cytokines
(biosynthesis)
- Female
- Humans
- Interferon-gamma
(biosynthesis)
- Interleukin-10
(biosynthesis)
- Interleukin-12
(biosynthesis)
- Interleukin-4
(biosynthesis)
- Lymphocyte Activation
- Male
- Middle Aged
|