Abstract |
The antipyretic activity of alpha-methyl--4-(2-thienylcarbonyl)benzeneacetic acid ( suprofen) was studied in rats with comparable hyperthermia after s.c. injection of brewer's yeast. The lowest dose effectively reducing fever is 5 mg/kg and restoration of normal body temperature is obtained with 40 mg/kg. Hypothermia is not observed even after treatment with 160 mg/kg. The ED50 (with confidence limits), which reduces fever below 39 degrees C in 50% of the animals, at the time of peak hyperthermia is 10.0 (6.6--15.2) mg/kg. ED50's of simultaneously studied reference compounds are 5.7 (3.9--8.3) mg/kg for indometacin, 38 (24--61) mg/kg for tolmetin, 76 (47--121) mg/kg for phenylburazone and 113 (75--170) mg/kg for acetyl- salicylic acid. Two to four times higher doses of these compounds restore normal body temperature but further increase of the dose induces hypothermia, which is particularly pronounced for acetyl- salicylic acid and phenylbutazone. Suprofen is a potent antipyretic agent, devoid of hypothermic activity even at 32 times the lowest effective dose.
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Authors | C J Niemegeers, F M Lenaerts, P A Janssen |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 25
Issue 10
Pg. 1519-24
(Oct 1975)
ISSN: 0004-4172 [Print] Germany |
PMID | 1243033
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Analgesics
- Phenylpropionates
- Thiophenes
- Tolmetin
- Phenylbutazone
- Aspirin
- Indomethacin
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Topics |
- Analgesics
(therapeutic use)
- Animals
- Aspirin
(therapeutic use)
- Body Temperature
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Fever
(drug therapy, etiology)
- Indomethacin
(therapeutic use)
- Male
- Phenylbutazone
(therapeutic use)
- Phenylpropionates
(therapeutic use)
- Rats
- Thiophenes
(therapeutic use)
- Time Factors
- Tolmetin
(therapeutic use)
- Yeast, Dried
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