[Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease].

Abstract

INTRODUCTION:

Vasculitis is a rare complication of antithyroid drugs reported with propylthiouracil, carbimazole, methimazole and we describe the first case with benzylthyouracil. Renal involvement during thyroid auto-immune diseases and during vasculitis as complication of antithyroid drugs will be discussed.

EXEGESIS:

We present a case study of 28-year-old female patient with Graves' disease diagnosed in 1996 and treated by benzylthiouracil for 2 years. The thyroid function was poorly controlled, so surgical treatment was indicated in May 1998. One month later, she developed vasculitis with pulmonary and renal involvement. Her renal function deteriorated rapidly. On admission, the additional laboratory findings showed hematuria, proteinuria of 1.44 g/day and serum creatinine level at 1000 mumol/l. She had myeloperoxidase-anti neutrophil cytoplasmic antibody, antithyroglobulin and antimicrosome antibodies. A renal biopsy revealed pauci-immune crescentic glomerulonephritis with 75% sclerous crescents. Chest-X-ray showed unilateral alveolar shadowing and a bronchio-alveolar lavage revealed lymphocytic alveolitis. She was treated with high dose of prednisolone and cyclophosphamide. After a follow-up of 18 months, the serum creatinine level decreased at 186 mumol/l and chest-X-ray returned to normal.

CONCLUSION:

Some cases of vasculitis associated with anti-thyroid drug treatment are reported.

• Authors: H Kaaroud, K Khiari, F Ben Moussa, S Barbouch, E Boussema, H Ben Maïz
• Journal: La Revue de medecine interne (Rev Med Interne) Vol. 23 Issue 10 Pg. 857-61 (Oct 2002) ISSN: 0248-8663 [Print] France
• Vernacular Title: Une vascularite associant une atteinte rénale et pulmonaire au cours d'une maladie de Basedow traitée par le benzylthiouracile.
• PMID: 12428490 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies
• anti-thyroglobulin
• Thiouracil
• benzylthiouracil

Topics

• Adult
• Antibodies, Antineutrophil Cytoplasmic (analysis)
• Autoantibodies (analysis)
• Female
• Glomerulonephritis (chemically induced)
• Graves Disease (drug therapy)
• Humans
• Lung Diseases, Interstitial (chemically induced)
• Thiouracil (adverse effects, analogs & derivatives, therapeutic use)
• Vasculitis (chemically induced)