[ANCA associated glomerulonephritis related to benzylthiouracil].

Abstract

INTRODUCTION:

Vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) have been reported in patients suffering from Graves' disease treated with anti-thyroid drugs and especially propylthiouracil (PTU).

EXEGESIS:

We report a case of Graves' disease treated with benzylthiouracil (Basdène). This therapy was complicated by acute renal insufficiency due to crescentic glomerulonephritis associated with pANCA. After benzylthiouracil withdrawal and under corticosteroids, renal insufficiency, biological inflammation and pANCA levels decreased.

CONCLUSION:

Similar vasculitis associated with pANCA secondary to anti-thyroid drugs, especially propylthiouracil, were described. This suggests a causal relation between drug and vasculitis. To our best knowledge, it is the first case of vasculitis secondary to benzylthiouracil.

• Authors: N Tieulie, Du Le Thi Huong, M Andreu, B Wechsler, L Mercadal, H Beaufils, M C Diermert, J C Piette
• Journal: La Revue de medecine interne (Rev Med Interne) Vol. 23 Issue 10 Pg. 853-6 (Oct 2002) ISSN: 0248-8663 [Print] France
• Vernacular Title: Glomérulonéphrite associée aux ANCA secondaire au benzylthiouracile.
• PMID: 12428489 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Thiouracil
• Uridine Phosphorylase
• benzylthiouracil

Topics

• Antibodies, Antineutrophil Cytoplasmic (immunology)
• Glomerulonephritis (chemically induced, immunology)
• Graves Disease (drug therapy)
• Humans
• Male
• Middle Aged
• Thiouracil (adverse effects, analogs & derivatives)
• Uridine Phosphorylase (antagonists & inhibitors)
• Vasculitis (chemically induced)