[Use of guthimine for treatment of intestinal paresis in peritonitis under experimental and clinical conditions].

Abstract

A new stimulator of intestinal peristalsis-guthymine (guanylthiourea) was used experimentally and clinically for treatment of the bowel paresis in peritonitis. Preliminary, in experiments on 53 rabbits with colibacillar peritonitis an efficacy of guthymine was compared with other stimulators of the gastrointestinal tract: proserine, a hypertonic solution of sodium chloride and sorbitol. Guthymine was found to be the most effective drug. Clinically, in 23 of 33 patients with intestinal paresis a drip administration of 15-50 mg/Kg of guthymine would provide for aborting the signs of paresis. In 8 patients a moderately pronounced effect was noted. In 2 cases the use of guthimine failed to produce any positive effects.

• Authors: N N Timofeev, S F Frolov, R I Zhitniuk
• Journal: Vestnik khirurgii imeni I. I. Grekova (Vestn Khir Im I I Grek) Vol. 115 Issue 8 Pg. 39-43 (Aug 1975) ISSN: 0042-4625 [Print] Russia (Federation)
• Vernacular Title: O primenenii gutimina dlia lecheniia pareza kishechnika pri peritonite v eksperimente i klinike
• PMID: 1242832 (Publication Type: English Abstract, Journal Article)

Chemical References

• Guanine
• Thiourea

Topics

• Animals
• Guanine (analogs & derivatives, pharmacology, therapeutic use)
• Humans
• Injections, Intravenous
• Intestinal Obstruction (drug therapy)
• Intestinal Pseudo-Obstruction (complications, drug therapy)
• Peristalsis (drug effects)
• Peritonitis (complications)
• Rabbits
• Thiourea (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)