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[The minimal freezing temperature for a necrosis of the epidermis and the influence of cryoprotective agents (author's transl)].

Abstract
The sensitiveness to cold of the epidermis (cold threshold) is determined on the auricular skin of 24 rabbits, using freezing temperatures of -10, -15, -20, -25, -30, and -40 degrees C and a freezing time of 30 sec. The experiments are performed with and without application of cryoprotective agents (DMSO, glycerol and aethanol in a 10% solution) before cryosurgery. Only at -20 degrees C a necrosis of the epidermis is seen whereas after application of cryoprotective agents before freezing a necrosis of the epidermis first appears at -30 degrees C. Following these experiments clinically it might be possible to protect the epidermis in the periphery of the freezing area up to a certain degree with the use of cryoprotective agents, so that a topographically more concentrated epidermis-necrosis and therefore a limitation of the cryoeffect to the epidermis to a certain degree could be possible.
AuthorsH Lenz, G Goertz, H Preussler
JournalArchives of oto-rhino-laryngology (Arch Otorhinolaryngol) Vol. 209 Issue 3 Pg. 217-21 (Jul 08 1975) ISSN: 0302-9530 [Print] Germany
Vernacular TitleDie Mindestgefriertemperatur für eine Hautnekrose und ihre Beeinflussung durch Kälteschutzsubstanzen
PMID1242648 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cryoprotective Agents
Topics
  • Animals
  • Cryoprotective Agents (pharmacology)
  • Cryosurgery (methods)
  • Ear
  • Necrosis
  • Rabbits
  • Skin Diseases (prevention & control)
  • Temperature

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