Abstract |
The sensitiveness to cold of the epidermis (cold threshold) is determined on the auricular skin of 24 rabbits, using freezing temperatures of -10, -15, -20, -25, -30, and -40 degrees C and a freezing time of 30 sec. The experiments are performed with and without application of cryoprotective agents ( DMSO, glycerol and aethanol in a 10% solution) before cryosurgery. Only at -20 degrees C a necrosis of the epidermis is seen whereas after application of cryoprotective agents before freezing a necrosis of the epidermis first appears at -30 degrees C. Following these experiments clinically it might be possible to protect the epidermis in the periphery of the freezing area up to a certain degree with the use of cryoprotective agents, so that a topographically more concentrated epidermis- necrosis and therefore a limitation of the cryoeffect to the epidermis to a certain degree could be possible.
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Authors | H Lenz, G Goertz, H Preussler |
Journal | Archives of oto-rhino-laryngology
(Arch Otorhinolaryngol)
Vol. 209
Issue 3
Pg. 217-21
(Jul 08 1975)
ISSN: 0302-9530 [Print] Germany |
Vernacular Title | Die Mindestgefriertemperatur für eine Hautnekrose und ihre Beeinflussung durch Kälteschutzsubstanzen |
PMID | 1242648
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Animals
- Cryoprotective Agents
(pharmacology)
- Cryosurgery
(methods)
- Ear
- Necrosis
- Rabbits
- Skin Diseases
(prevention & control)
- Temperature
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