A case of biphenotypic blast crisis of unclassified myeloproliferative disorder.

Abstract

We report a first case of biphenotypic blast crisis of unclassified myeloproliferative disorder (MPD). A 20-year-old patient presented with fever, splenomegaly, marked leukocytosis (603 x 10(3)/ micro l), and blasts in the peripheral blood. Since Ph chromosome and bcr-abl gene rearrangement were absent, the diagnosis of an unclassified MPD in the blast crisis phase was established. Immunophenotyping confirmed a biphenotypic crisis of myeloid and T-lymphoid antigens. The patient went into a complete remission after chemotherapy, but marked granulocytic hyperplasia (M:E ratio of 5.7) and 90% cellularity remained. Blast crisis recurred during subsequent intensification chemotherapy and the patient did not go into a complete remission regardless of the intense chemotherapy. The blast crisis transformed from unclassified MPD had a grave prognosis as it responded poorly to chemotherapy. This unique blast crisis is distinguishable from the blast crisis of chronic myelogenous leukemia.

• Authors: J Kim, C J Park, E J Seo, J H Lee, S J Yoo, S J Choi, H S Chi
• Journal: Annals of hematology (Ann Hematol) Vol. 81 Issue 10 Pg. 603-4 (Oct 2002) ISSN: 0939-5555 [Print] Germany
• PMID: 12424544 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Blast Crisis (diagnosis, pathology)
• Cytogenetic Analysis
• Humans
• Male
• Myeloid Cells (pathology)
• Myeloproliferative Disorders (classification, pathology)
• Phenotype
• T-Lymphocytes (pathology)