Synthesis of natural beta-D-(1-->3)-glucopyranosyl oligosaccharides.

Abstract

beta-D-(1-->3)-Glucan core structure derivatives corresponding to schizophyllan, epiglucan and lentinan were synthesized efficiently. 4,6-O-Benzylidenated glucopyranosyl acceptors were found to be helpful in the attempted beta-D-(1-->3) bond formation. The epiglucan pentasaccharide showed a weak anti-tumor activity in preliminary mice tests.

• Authors: Hongmei He, Feng Yang, Yuguo Du
• Journal: Carbohydrate research (Carbohydr Res) Vol. 337 Issue 18 Pg. 1673-8 (Oct 08 2002) ISSN: 0008-6215 [Print] Netherlands
• PMID: 12423970 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Benzylidene Compounds
• Oligosaccharides

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Benzylidene Compounds (chemistry)
• Carbohydrate Conformation
• Carbohydrate Sequence
• Glycosylation
• Magnetic Resonance Spectroscopy
• Mice
• Molecular Sequence Data
• Oligosaccharides (chemistry, pharmacology)
• Optical Rotation
• Sarcoma (metabolism)
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization (methods)