The regulation of microcin B, C and J operons.

Abstract

Microcins are ribosomally encoded small peptide antibiotics produced by Gram(-) enterobacteria. Microcin production-biosynthesis, maturation and secretion to the medium-is encoded by gene clusters organized in operons. Production of the best known plasmid-encoded microcins (MccB, MccC and MccJ) switches on when cells reach the stationary growth phase. This production is doubly regulated at transcriptional level by (a). the growth phase: microcin operons silent/repressed during exponential growth are induced/derepressed when cells sense nutrient starvation and stop exponential growth, and (b). global bacterial regulators acting as inducers or repressors of operon expression. The role played by these regulators (CRP, EmrR, IHF, H-NS, LRP, OmpR, Sigma-38 and SpoT) in the expression of specific microcin operons is reviewed.

• Authors: Felipe Moreno, José Eduardo Gónzalez-Pastor, Maria Rosario Baquero, Daniel Bravo
• Journal: Biochimie (Biochimie) 2002 May-Jun Vol. 84 Issue 5-6 Pg. 521-9 ISSN: 0300-9084 [Print] France
• PMID: 12423796 (Publication Type: Journal Article, Review)

Chemical References

• Bacteriocins
• Recombinant Fusion Proteins
• microcin
• Glucose

Topics

• Bacteriocins (genetics, metabolism)
• Base Sequence
• Enterobacteriaceae (genetics, physiology)
• Gene Expression Regulation, Bacterial (physiology)
• Genes, Regulator
• Genes, Reporter (physiology)
• Glucose (metabolism)
• Molecular Sequence Data
• Recombinant Fusion Proteins (metabolism)
• Sequence Analysis, DNA