Abstract | PURPOSE: METHODS:
Fluoxetine (20 mg/kg) and TFMPP (5 mg/kg) were administered to rats with pilocarpine-induced epilepsy. Phenobarbital (PB; 10 mg/kg) was a positive control, and saline (i.e., 0.5 ml) controlled for the injection protocol. Each rat received each treatment (intraperitoneally) once per day for 5 consecutive days with 1 week between treatments. Rats were continuously video-monitored for the last 72 h of each treatment. RESULTS: When compared with saline over the entire 72-h observation period, PB and fluoxetine treatment, but not TFMPP, reduced the spontaneous-seizure rate. Plots of magnitude of the drug effect as a function of seizure frequency after saline treatment revealed larger drug effects for fluoxetine and PB in the rats with the highest control seizure rate. When the data from the five rats with the highest seizure frequency in saline were analyzed for the first 6 h after treatment, TFMPP also significantly reduced seizure frequency. CONCLUSIONS:
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Authors | Eric J Hernandez, Philip A Williams, F Edward Dudek |
Journal | Epilepsia
(Epilepsia)
Vol. 43
Issue 11
Pg. 1337-45
(Nov 2002)
ISSN: 0013-9580 [Print] United States |
PMID | 12423383
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Convulsants
- Piperazines
- Serotonin Receptor Agonists
- Serotonin Uptake Inhibitors
- Fluoxetine
- Pilocarpine
- 1-(3-trifluoromethylphenyl)piperazine
- Sodium Chloride
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Topics |
- Animals
- Convulsants
- Epilepsy
(chemically induced, physiopathology)
- Fluoxetine
(pharmacology)
- Male
- Pilocarpine
- Piperazines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Serotonin Receptor Agonists
(pharmacology)
- Selective Serotonin Reuptake Inhibitors
(pharmacology)
- Sodium Chloride
(pharmacology)
- Time Factors
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