Abstract | OBJECTIVE: METHODS: The prospective, randomized, controlled animal study set in a research laboratory in a university hospital used 280 adult male Wistar rats (weight range, 280 to 350 g). Graft infections were established in the back subcutaneous tissue of rats with implantation of 1-cm(2) sterile Dacron grafts followed by topical inoculation with 2 x 10(7) colony-forming units of S epidermidis. The study for each staphylococcal strain included: one control group (no graft contamination), one contaminated group that did not receive any antibiotic prophylaxis, one contaminated group that received temporin A-soaked graft, two contaminated groups that received perioperative intraperitoneal cefazolin (30 mg/kg) or vancomycin hydrochloride prophylaxis (10 mg/kg), and two contaminated groups that received temporin A-soaked graft and perioperative intraperitoneal cefazolin (30 mg/kg) or vancomycin hydrochloride (10 mg/kg) prophylaxis. All grafts were explanted at 7 days after implantation. The main outcome measure was quantification of bacterial contamination. RESULTS: CONCLUSION:
Temporin A showed a similar antibacterial in vitro activity against the two different strains. The in vivo results suggest its potential use in providing prophylaxis to direct graft contamination when used in combination with parenteral vancomycin hydrochloride.
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Authors | Roberto Ghiselli, Andrea Giacometti, Oscar Cirioni, Federico Mocchegiani, Fiorenza Orlando, Wojciech Kamysz, Maria Simona Del Prete, Jerzy Lukasiak, Giorgio Scalise, Vittorio Saba |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 36
Issue 5
Pg. 1027-30
(Nov 2002)
ISSN: 0741-5214 [Print] United States |
PMID | 12422090
(Publication Type: Journal Article)
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Chemical References |
- Antimicrobial Cationic Peptides
- Proteins
- temporin
- Vancomycin
- Cefazolin
- Methicillin
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Topics |
- Animals
- Antibiotic Prophylaxis
- Antimicrobial Cationic Peptides
- Blood Vessel Prosthesis
- Cefazolin
(therapeutic use)
- Male
- Methicillin
(pharmacology)
- Methicillin Resistance
- Prosthesis-Related Infections
(prevention & control)
- Proteins
(therapeutic use)
- Rats
- Rats, Wistar
- Staphylococcal Infections
(prevention & control)
- Staphylococcus epidermidis
(drug effects)
- Vancomycin
(therapeutic use)
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