Abstract | OBJECTIVE: To review the current understanding of the pathophysiology of protein C deficiency and its role in congenital thrombophilia. Recommendations for diagnostic testing for protein C function and concentration, derived from the medical literature and consensus opinions of recognized experts in the field, are included, specifying whom, how, and when to test. The role of related proteins, such as thrombomodulin and endothelial protein C receptor, is also reviewed. Data Sources.-Review of the published medical literature. DATA EXTRACTION AND SYNTHESIS: A summary of the medical literature and proposed testing recommendations were prepared and presented at the College of American Pathologists Conference XXXVI: Diagnostic Issues in Thrombophilia. After discussion at the conference, consensus recommendations presented in this manuscript were accepted after a two-thirds majority vote by the participants. CONCLUSIONS:
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Authors | Kandice Kottke-Marchant, Philip Comp |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 126
Issue 11
Pg. 1337-48
(Nov 2002)
ISSN: 0003-9985 [Print] United States |
PMID | 12421141
(Publication Type: Journal Article, Review)
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Chemical References |
- Blood Coagulation Factors
- Protein C
- Receptors, Cell Surface
- Thrombomodulin
- activated protein C receptor
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Topics |
- Blood Coagulation Factors
(metabolism)
- Humans
- Practice Guidelines as Topic
- Protein C
(metabolism)
- Protein C Deficiency
(complications, diagnosis, metabolism)
- Receptors, Cell Surface
(metabolism)
- Risk Factors
- Thrombomodulin
(metabolism)
- Thrombophilia
(diagnosis, etiology, metabolism)
- Thrombosis
(diagnosis, etiology, metabolism)
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