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Central 5-HT(3) receptors and water intake in rats.

Abstract
In the present paper, we studied in rats the effect of third ventricle administration of m-chlorophenylbiguanide hydrochloride (1-(3-chlorophenyl)biguanide (m-CPBG), a selective 5-HT(3) agonist, on water intake induced by three different physiological stimuli: water deprivation, acute salt load and hypovolemia. Central acute m-CPBG injections in the doses of 80 and 160 nmol significantly reduced water intake elicited by an acute salt load. Third ventricle injections of m-CPBG in the dose of 160 nmol significantly inhibited water intake in hypovolemic animals, whereas third ventricle injections of m-CPBG in a higher dose (320 nmol) were necessary to decrease water intake in water-deprived rats. Pretreatment with 1-methyl-N-[8-methyl-8-azabicyclo(3.2.1)-oct-3-yl]-1H-indazole-3-carboxamide (LY-278,584), a selective 5-HT(3) antagonist, abolished the inhibitory effect on water intake seen after central administration of m-CPBG in all groups studied. The central administration of m-CPBG was also able to inhibit water intake induced by pharmacological activation of central cholinergic and angiotensinergic pathways. Third ventricle injections of m-CPBG in the highest dose employed in this study (320 nmol) were unable to modify food intake in food-deprived rats. An aversion test has shown that acute third ventricle injections of m-CPBG do not induce illness-like effects that could explain the water intake inhibition here observed. Also, central administration of m-CPBG did not modify the intake of a "dessert" meal consisting of diluted condensed milk. It is concluded that central 5-HT(3) receptor activation exerts a specific inhibitory effect on water intake.
AuthorsLetícia Castro, Bruno Varjão, Igor Maldonado, Igor Campos, Bruno Duque, Josmara Fregoneze, Irismar Reis de Oliveira, Emílio De Castro-e-Silva
JournalPhysiology & behavior (Physiol Behav) Vol. 77 Issue 2-3 Pg. 349-59 (Nov 2002) ISSN: 0031-9384 [Print] United States
PMID12419412 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiotensins
  • Biguanides
  • Indazoles
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT3
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Tropanes
  • LY 278584
  • Polyethylene Glycols
  • 1-(3-chlorophenyl)biguanide
Topics
  • Angiotensins (physiology)
  • Animals
  • Autonomic Pathways (drug effects, physiology)
  • Avoidance Learning (drug effects)
  • Biguanides (pharmacology)
  • Brain Chemistry (drug effects)
  • Drinking (drug effects)
  • Eating (drug effects)
  • Indazoles (pharmacology)
  • Injections, Intraventricular
  • Male
  • Motor Activity (drug effects)
  • Osmolar Concentration
  • Parasympathetic Nervous System (physiology)
  • Polyethylene Glycols (pharmacology)
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin (drug effects)
  • Receptors, Serotonin, 5-HT3
  • Serotonin Antagonists (pharmacology)
  • Serotonin Receptor Agonists (pharmacology)
  • Tropanes (pharmacology)
  • Water Deprivation (physiology)

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