Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.

Abstract	The anti-influenza activity of a series of thiobenzamide fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine is profiled. Axial disposition of the thioamide moiety is essential for potent influenza inhibitory activity.
Authors	Kuo Long Yu, Albert F Torri, Guangxiang Luo, Christopher Cianci, Katharine Grant-Young, Stephanie Danetz, Lawrence Tiley, Mark Krystal, Nicholas A Meanwell
Journal	Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 12 Issue 23 Pg. 3379-82 (Dec 02 2002) ISSN: 0960-894X [Print] England
PMID	12419365 (Publication Type: Journal Article)
Chemical References	Antiviral Agents BMY 27709 Methylamines Quinolizines Thioamides thiobenzamide methylamine
Topics	Animals Antiviral Agents (chemistry, pharmacology) Cells, Cultured Dogs Drug Evaluation, Preclinical Hemolysis (drug effects) Inhibitory Concentration 50 Membrane Fusion (drug effects) Methylamines (chemistry, pharmacology) Orthomyxoviridae (drug effects) Quinolizines (chemistry, pharmacology) Stereoisomerism Structure-Activity Relationship Thioamides (chemistry, pharmacology)

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