Abstract |
The anti- influenza activity of a series of thiobenzamide fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine is profiled. Axial disposition of the thioamide moiety is essential for potent influenza inhibitory activity.
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Authors | Kuo Long Yu, Albert F Torri, Guangxiang Luo, Christopher Cianci, Katharine Grant-Young, Stephanie Danetz, Lawrence Tiley, Mark Krystal, Nicholas A Meanwell |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 12
Issue 23
Pg. 3379-82
(Dec 02 2002)
ISSN: 0960-894X [Print] England |
PMID | 12419365
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- BMY 27709
- Methylamines
- Quinolizines
- Thioamides
- thiobenzamide
- methylamine
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Topics |
- Animals
- Antiviral Agents
(chemistry, pharmacology)
- Cells, Cultured
- Dogs
- Drug Evaluation, Preclinical
- Hemolysis
(drug effects)
- Inhibitory Concentration 50
- Membrane Fusion
(drug effects)
- Methylamines
(chemistry, pharmacology)
- Orthomyxoviridae
(drug effects)
- Quinolizines
(chemistry, pharmacology)
- Stereoisomerism
- Structure-Activity Relationship
- Thioamides
(chemistry, pharmacology)
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