Abstract | OBJECTIVE: DESIGN: Case report (two cases) and review of the literature. SETTING: Neonatal intensive care unit, university teaching hospital. PATIENTS: Two preterm neonates with life-threatening hemorrhages, from the liver and spleen in one patient and from the lung in the other. INTERVENTION: MEASUREMENTS AND RESULTS: Complete hemostasis 10 min after the second bolus in the two patients. CONCLUSION: For the intensivist, the successful use of rFVIIa in these patients and others lacking pre-existing coagulopathies points to rFVIIa as a novel therapeutic approach for patients presenting with massive life-threatening hemorrhage.
|
Authors | Alex Veldman, Doris Fischer, Burkhard Voigt, Peter A Beyer, Rolf Schlösser, Antje Allendorf, Wolfhardt Kreuz |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 28
Issue 11
Pg. 1635-7
(Nov 2002)
ISSN: 0342-4642 [Print] United States |
PMID | 12415453
(Publication Type: Case Reports, Journal Article, Review)
|
Chemical References |
- Recombinant Proteins
- Factor VII
|
Topics |
- Factor VII
(therapeutic use)
- Fatal Outcome
- Hemorrhage
(drug therapy, etiology)
- Humans
- Infant, Newborn
- Infant, Premature
- Intensive Care Units, Neonatal
- Male
- Recombinant Proteins
(therapeutic use)
|