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Myocardial and endocardial lesions in rabbit after acute poisoning with Intration and after treatment with some detoxifying agents.

Abstract
The hearts of rabbits killed 24 hours after intoxication with Intration in the dose of LD50 and rabbits treated at the same time with PAM or atropine were studied pathomorphologically. Twenty-four hours after administration of Intration toxic lesions of the myocardium and endocardium were observed, which were more pronounced in rabbits treated simultaneously with the detoxifying agents as compared with those which received only Intration. The intensity of the changes was due to overdosage of the detoxifying agents, especially PAM which was particularly harmful.
AuthorsS Biernat, H Giermaziak
JournalPolish medical sciences and history bulletin (Pol Med Sci Hist Bull (1973)) 1975 Mar-Apr Vol. 15 Issue 2 Pg. 249-53 ISSN: 0301-0236 [Print] Poland
PMID1241438 (Publication Type: Journal Article)
Chemical References
  • Insecticides
  • Organothiophosphorus Compounds
  • Pralidoxime Compounds
  • Atropine
Topics
  • Animals
  • Atropine (adverse effects, therapeutic use)
  • Endocardium (pathology)
  • Heart (drug effects)
  • Insecticides (poisoning)
  • Myocardium (pathology)
  • Necrosis
  • Organothiophosphorus Compounds
  • Pralidoxime Compounds (adverse effects, therapeutic use)
  • Rabbits

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