| Abstract | Brucellosis vaccines are essential elements in control programs. Since first developed in the mid-1950s, the Brucella melitensis vaccine strain Rev.1 has been used worldwide and its significant value in protecting sheep and goats in endemic areas recognized. This review provides historical background on the development of the vaccine, its use and field complications arising in Israel following changes in the strain's pathogenicity. The urgent need for resolving cases of vaccine strain excretion in the milk, horizontal transfer and a unique case of human infection has led to identification of an atypical B. melitensis biovar 1 strain that resembles strain Rev.1 in susceptibility to penicillin and dyes. An omp2 based PCR method has been developed that traced the lineage of Israeli B. melitensis biovar 1 strains. This locus serves as an epidemiological tag for the Rev.1 vaccine strain. Despite the rapid development of new approaches in the field of vaccination, it is anticipated that in the near future the Rev.1 vaccine would remain the only accepted vaccine in national control programs. |
| Authors | Menachem Banai
(Affiliation: Department of Bacteriology, Kimron Veterinary Institute, PO Box 12, Bet Dagan 50250, Israel. mbana_vs at netvision.net.il)
|
| Journal | Veterinary microbiology
(Vet Microbiol)
Vol. 90
Issue 1-4
Pg. 497-519
(Dec 20 2002)
ISSN: 0378-1135 Netherlands |
| PMID | 12414167
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)
|
| Copyright | Copyright 2002 Elsevier Science B.V. |
| Chemical References |
- Bacterial Vaccines
- Rev.1 vaccine, Brucella melitensis
|
| Topics |
- Animals
- Bacterial Vaccines
(immunology)
- Brucella melitensis
(immunology)
- Brucellosis
(immunology, prevention & control, veterinary)
- Ruminants
|
