HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Leukocyte count is associated with aortic arch plaque thickness.

AbstractBACKGROUND AND PURPOSE:
Leukocyte count has been associated with cardiovascular and cerebrovascular disease, including carotid plaque thickness, in several studies. We hypothesized that white blood cell count is associated with aortic arch plaque thickness (AAPT).
METHODS:
Leukocyte count was measured in randomly selected stroke-free community participants undergoing transesophageal echocardiography. AAPT was measured for each subject and dichotomized into <4 and > or =4 mm (thick plaque). Multivariate linear and logistic regression was used to calculate the effect of leukocyte count on AAPT after adjustment for potential confounding factors. Mean age of the 145 participants was 68.5+/-8.3 years; 43.5% were women; 15.9% were white; 31.7% were black; and 49.0% were Hispanic.
RESULTS:
Mean leukocyte count was 5.88+/-1.76x10(9)/L. Each unit increase in leukocyte count was associated with a mean 0.28-mm increase in AAPT (P=0.0036). After adjustment for other atherosclerosis risk factors, including age, sex, hypertension, diabetes, hyperlipidemia, and smoking, the relationship persisted (mean increase in AAPT, 0.24 mm; P=0.0064). Thirty-five participants (24.1%) had AAPT > or =4 mm. Mean leukocyte count among those with thick plaque was significantly higher than among those with plaque <4 mm (6.54+/-1.60 versus 5.65+/-1.76x10(9)/L, respectively; P=0.009). Each unit increase in leukocyte count was associated with an increased risk of thick plaque (adjusted odds ratio, 1.38; 95% CI, 1.05 to 1.79). The relationships were similar for men and women and for those <70 or > or =70 years of age.
CONCLUSIONS:
Leukocyte count is associated with AAPT and is specifically correlated with AAPT > or =4 mm, a degree of thickening associated with increased stroke risk. These findings are consistent with current hypotheses regarding the inflammatory or infectious etiology of risk of atherosclerosis and stroke.
AuthorsMitchell S V Elkind, Robert Sciacca, Bernadette Boden-Albala, Shunichi Homma, Marco R Di Tullio
JournalStroke (Stroke) Vol. 33 Issue 11 Pg. 2587-92 (Nov 2002) ISSN: 1524-4628 [Electronic] United States
PMID12411647 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • C-Reactive Protein
Topics
  • Age Distribution
  • Aged
  • Aorta, Thoracic (diagnostic imaging)
  • Arteriosclerosis (diagnostic imaging, epidemiology, immunology)
  • Black People
  • C-Reactive Protein (analysis)
  • Chlamydophila Infections (epidemiology, immunology)
  • Chlamydophila pneumoniae (immunology)
  • Cohort Studies
  • Comorbidity
  • Cross-Sectional Studies
  • Echocardiography, Transesophageal
  • Female
  • Hispanic or Latino (statistics & numerical data)
  • Humans
  • Leukocyte Count (statistics & numerical data)
  • Linear Models
  • Male
  • New York City (epidemiology)
  • Odds Ratio
  • Risk Factors
  • Serologic Tests
  • Severity of Illness Index
  • Sex Distribution
  • Stroke
  • White People

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: