Abstract | OBJECTIVE: To determine the relationships of Met416Val and XbaI polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the beta(3)-adrenergic-receptor (beta(3)-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population. METHODS: Polymerase chain reaction- oligonucleotide ligation assay and restriction fragment length polymorphism assay were used to evaluate the GYS1 and beta(3)-AR gene polymorphisms in 102 pairs of case-control Chinese spouses. RESULTS: Subjects with Met416Val variant had a significantly higher 2-hour post- glucose level than subjects without this variant had in diabetic group (P = 0.032). The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR = 1.67; 95% CI: 0.73 - 3.81, P = 0.223). Subjects with Trp64Arg variant had a significantly higher serum uric acid level than subjects without this variant had in diabetic group (P = 0.034). The combination of BMI and Arg64 allele carrier of the beta(3)-AR gene increased the diabetic risk over four-fold (adjusted OR = 4.00; 95% CI: 1.53 - 10.45, P = 0.005). CONCLUSIONS: In the Chinese population, Met416Val polymorphism is identified in a subgroup of diabetic subjects with high 2-hour post- glucose. It will explain why some diabetic patients appear to be genetically predisposed to developing high postpradial glucose level. The presence of the Arg64 allele in the beta(3)-AR gene may predispose patients to higher serum uric acid level.
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Authors | Guoying Wang, Qiongfang Li, Tianhua Niu, Changzhong Chen, Xiping Xu |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 115
Issue 9
Pg. 1308-11
(Sep 2002)
ISSN: 0366-6999 [Print] China |
PMID | 12411100
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Adrenergic, beta-3
- Uric Acid
- Glycogen Synthase
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Topics |
- Adult
- Aged
- Alleles
- Body Mass Index
- Diabetes Mellitus, Type 2
(blood, genetics)
- Glycogen Synthase
(genetics)
- Humans
- Hyperglycemia
(genetics)
- Middle Aged
- Polymorphism, Genetic
- Postprandial Period
(physiology)
- Receptors, Adrenergic, beta-3
(genetics)
- Uric Acid
(blood)
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