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Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus.

AbstractOBJECTIVE:
To determine the relationships of Met416Val and XbaI polymorphism of muscle glycogen synthase (GYS1) gene and Trg64Arg variant of the beta(3)-adrenergic-receptor (beta(3)-AR) gene with type 2 diabetes mellitus (DM) and its intermediate phenotypes in the Chinese population.
METHODS:
Polymerase chain reaction-oligonucleotide ligation assay and restriction fragment length polymorphism assay were used to evaluate the GYS1 and beta(3)-AR gene polymorphisms in 102 pairs of case-control Chinese spouses.
RESULTS:
Subjects with Met416Val variant had a significantly higher 2-hour post-glucose level than subjects without this variant had in diabetic group (P = 0.032). The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR = 1.67; 95% CI: 0.73 - 3.81, P = 0.223). Subjects with Trp64Arg variant had a significantly higher serum uric acid level than subjects without this variant had in diabetic group (P = 0.034). The combination of BMI and Arg64 allele carrier of the beta(3)-AR gene increased the diabetic risk over four-fold (adjusted OR = 4.00; 95% CI: 1.53 - 10.45, P = 0.005).
CONCLUSIONS:
In the Chinese population, Met416Val polymorphism is identified in a subgroup of diabetic subjects with high 2-hour post-glucose. It will explain why some diabetic patients appear to be genetically predisposed to developing high postpradial glucose level. The presence of the Arg64 allele in the beta(3)-AR gene may predispose patients to higher serum uric acid level.
AuthorsGuoying Wang, Qiongfang Li, Tianhua Niu, Changzhong Chen, Xiping Xu
JournalChinese medical journal (Chin Med J (Engl)) Vol. 115 Issue 9 Pg. 1308-11 (Sep 2002) ISSN: 0366-6999 [Print] China
PMID12411100 (Publication Type: Journal Article)
Chemical References
  • Receptors, Adrenergic, beta-3
  • Uric Acid
  • Glycogen Synthase
Topics
  • Adult
  • Aged
  • Alleles
  • Body Mass Index
  • Diabetes Mellitus, Type 2 (blood, genetics)
  • Glycogen Synthase (genetics)
  • Humans
  • Hyperglycemia (genetics)
  • Middle Aged
  • Polymorphism, Genetic
  • Postprandial Period (physiology)
  • Receptors, Adrenergic, beta-3 (genetics)
  • Uric Acid (blood)

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