| Abstract | A double-blind, placebo-controlled study was conducted to measure the impact of malaria prophylaxis with atovaquone/proguanil (A-P) on the immunogenicity of vaccines against typhoid fever and cholera, Salmonella serotype Typhi Ty21a and Vibrio cholerae CVD103-HgR, respectively. A total of 330 Gabonese schoolchildren were assigned to receive either A-P or placebo for 12 weeks. Vaccination occurred 3 weeks after the start of prophylaxis, and immunogenicity was assessed 4 weeks after vaccination. The protective efficacy of A-P against Plasmodium falciparum malaria was of 97% (95% confidence interval, 79%-100%). The 2 treatment groups did not differ significantly with regard to changes in antibody titers after vaccination (P=.96 for anti-S. Typhi IgG antibodies, P=.07 for anti-S. Typhi IgA antibodies, and P=.64 for vibriocidal antibodies). The A-P combination was highly effective for malaria prophylaxis, without interfering with the in vivo immunogenicity of CVD103-HgR and Ty21a vaccines, and it could therefore be simultaneously administered with these vaccines. |
| Authors | Jean-François Faucher, Ronnie Binder, Michel A Missinou, Pierre-Blaise Matsiegui, Holger Gruss, Rajko Neubauer, Bertrand Lell, John U Que, Gerri B Miller, Peter G Kremsner
(Affiliation: Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon.)
|
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 35
Issue 10
Pg. 1147-54
(Nov 15 2002)
ISSN: 1537-6591 United States |
| PMID | 12410473
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antimalarials
- Cholera Vaccines
- Naphthoquinones
- Typhoid-Paratyphoid Vaccines
- Chloroguanide
- Atovaquone
|
| Topics |
- Administration, Oral
- Adolescent
- Antimalarials
(pharmacology, therapeutic use)
- Atovaquone
- Chemoprevention
- Child
- Child, Preschool
- Chloroguanide
(pharmacology, therapeutic use)
- Cholera Vaccines
(administration & dosage, immunology)
- Double-Blind Method
- Female
- Humans
- Immunity
(drug effects)
- Malaria
(prevention & control)
- Male
- Naphthoquinones
(pharmacology, therapeutic use)
- Treatment Outcome
- Typhoid-Paratyphoid Vaccines
(administration & dosage, immunology)
|
