Prior poliomyelitis-evidence of cytokine production in the central nervous system.

Abstract

In order to study the role of a possible inflammatory reaction in the post-polio syndrome (PPS) four key cytokines were determined by means of mRNA expression in mononuclear cells from cerebrospinal fluid (CSF) and peripheral blood of 13 patients. Data were compared with those of samples from eight non-inflammatory control persons. The PPS-patients displayed increased numbers of CSF cells expressing mRNA for TNF-alpha (p<0.02), IFN-gamma (p<0.02), IL-4 (p<0.001) and IL-10 (p<0.05), in comparison to the non-inflammatory controls. As positive controls, samples from patients with Multiple Sclerosis (MS) were examined. We conclude that there is a chronic intra CNS expression of inflammatory cytokines in PPS, in the range of that in MS, a well known neuroinflammatory disease. However, the pathogenic significance of this is unclear.

• Authors: Henrik Gonzalez, Mohsen Khademi, Magnus Andersson, Erik Wallström, Kristian Borg, Tomas Olsson
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 205 Issue 1 Pg. 9-13 (Dec 15 2002) ISSN: 0022-510X [Print] Netherlands
• PMID: 12409177 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Interleukin-18
• RNA, Messenger
• Tumor Necrosis Factor-alpha
• Interleukin-10
• Interleukin-4

Topics

• Aged
• Central Nervous System (metabolism)
• Cytokines (blood, cerebrospinal fluid, genetics, metabolism)
• Female
• Humans
• In Situ Hybridization
• Interleukin-10 (genetics, metabolism)
• Interleukin-18 (genetics)
• Interleukin-4 (genetics, metabolism)
• Leukocytes, Mononuclear (metabolism)
• Male
• Middle Aged
• Multiple Sclerosis (blood, cerebrospinal fluid, genetics, metabolism)
• Polymerase Chain Reaction (methods)
• Postpoliomyelitis Syndrome (blood, cerebrospinal fluid, genetics, metabolism)
• RNA, Messenger (biosynthesis, blood, cerebrospinal fluid)
• Tumor Necrosis Factor-alpha (genetics, metabolism)