HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Biomarkers for endocrine disruptors in three species of Mediterranean large pelagic fish.

Abstract
The hypothesis that Mediterranean top predator species, such as large pelagic fish, are potentially at risk due to endocrine disrupting chemicals (EDCs), is investigated. The potential estrogenic effects of PHAHs in three fish species of commercial interest, the top predators bluefin tuna (Thunnus thynnus thynnus), swordfish (Xiphias gladius), and Mediterranean spearfish (Tetrapturus belone), were investigated using vitellogenin (Vtg), zona radiata proteins (Zrp) and mixed function oxidases (EROD, BPMO) as diagnostic tools. High induction of Vtg and Zrp was detected by western blot and ELISA techniques in adult males of X. gladius and T. thynnus thynnus, suggesting that these species are at high toxicological risk in the Mediterranean sea. Comparison of BPMO and EROD activities in the three species indicated, both in male and female, much higher MFO activity in bluefin tuna. This data suggests high exposure of this species to lipophilic xenobiotic contaminants in the Mediterranean environment.
AuthorsM C Fossi, S Casini, L Marsili, G Neri, G Mori, S Ancora, A Moscatelli, A Ausili, G Notarbartolo-di-Sciara
JournalMarine environmental research (Mar Environ Res) 2002 Sep-Dec Vol. 54 Issue 3-5 Pg. 667-71 ISSN: 0141-1136 [Print] England
PMID12408633 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Egg Proteins
  • Vitellogenins
  • Water Pollutants, Chemical
  • Xenobiotics
  • zona radiata protein, fish
  • Mixed Function Oxygenases
Topics
  • Animals
  • Biomarkers (analysis)
  • Egg Proteins (analysis, biosynthesis)
  • Endocrine System (drug effects)
  • Environmental Exposure
  • Female
  • Male
  • Mixed Function Oxygenases (analysis, pharmacology)
  • Perciformes (physiology)
  • Vitellogenins (analysis, biosynthesis)
  • Water Pollutants, Chemical (adverse effects)
  • Xenobiotics (adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: