Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus.

Abstract

The goal of this study was to assess the interactive effects of a polynuclear aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), and a co-planar halogenated aromatic hydrocarbon (HAH), 3,3'4,4'5-pentachlorobiphenyl (PCB 126) on ethoxyresorufin-O-deethylase (EROD) activity and occurrence of deformities in Fundulus heteroclitus. While each compound administered alone elicited dose-dependent increases in EROD activity, the combined treatment of these two compounds generally did not elicit an additive EROD response. There was a significant correlation between deformity occurrence and EROD induction in embryos dosed with PCB alone but not for embryos dosed with BaP alone, or a combination of BaP and PCB 126.

• Authors: Deena M Wassenberg, Erin E Swails, Richard T Di Giulio
• Journal: Marine environmental research (Mar Environ Res) 2002 Sep-Dec Vol. 54 Issue 3-5 Pg. 279-83 ISSN: 0141-1136 [Print] England
• PMID: 12408577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Estrogen Antagonists
• Benzo(a)pyrene
• Polychlorinated Biphenyls
• Cytochrome P-450 CYP1A1
• 3,4,5,3',4'-pentachlorobiphenyl

Topics

• Animals
• Benzo(a)pyrene (adverse effects)
• Carcinogens (adverse effects)
• Congenital Abnormalities (etiology, veterinary)
• Cytochrome P-450 CYP1A1 (drug effects, pharmacology)
• Dose-Response Relationship, Drug
• Drug Interactions
• Embryo, Nonmammalian (drug effects)
• Embryonic Development
• Environmental Exposure
• Enzyme Induction
• Estrogen Antagonists (adverse effects)
• Fundulidae (embryology, physiology)
• Polychlorinated Biphenyls (adverse effects)