[Anti-edematous action of 1-(m-chlorophenyl)-3-N, N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)].

Abstract

From the screening of a number of new pyrazole derivatives, the title compound, PZ-177, was selected as the most significant derivative for analgestic and anti-edematous actions, in this paper, we report the anti-edematous activity of PZ-177 as assessed by detailed analysis. PZ-177 showed a markedly inhibitory effect against rat paw edema induced by various phlogists (carragenin, dextran, egg albumin, serotonin, formalin and bradykinin). It also inhibited edema induced by anti-rat rabbit serum. The activity of PZ-177 was more potent than that of mepirizole and the same as that of phenylbutazone. Though this agent has a central depressive effect, it is considered that the action has actually little influence on anti-edematous effect, as carrageenin-induced edema was inhibited in spinal rats. On the other hand, the anti-edematous effect of PZ-177 was reduced significantly in adrenalectomized rats. It is therefore suggested that the potent anti-edematous action of PZ-177 is exerted partially by a direct action at the inflamed site and mediated partially by stimulation of the hypophysis-adrenal system.

• Authors: K Tsurumi, A Abe, T Shibuya, H Fujimura
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 71 Issue 8 Pg. 833-41 (Nov 1975) ISSN: 0015-5691 [Print] Japan
• PMID: 1240833 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Pyrazoles
• Formaldehyde
• Serotonin
• Epirizole
• PZ 177
• Carrageenan
• Ovalbumin
• Bradykinin

Topics

• Animals
• Anti-Inflammatory Agents
• Bradykinin
• Carrageenan
• Drug Evaluation, Preclinical
• Edema (chemically induced, drug therapy)
• Epirizole (therapeutic use)
• Formaldehyde
• Ovalbumin
• Pyrazoles (therapeutic use)
• Rats
• Serotonin