Evidence for the efficacy of artesunate in asymptomatic Plasmodium malariae infections.

Abstract

This study evaluated the efficacy and safety of a 3-day course of artesunate (4 mg/kg/day) for asymptomatic Plasmodium malariae infections. The parasitological cure rates on days 7 and 56 in the group treated with artesunate were 100% and 83%, respectively, compared with no cure in the placebo group (P < 0.0001).

• Authors: Steffen Borrmann, Nicole Szlezák, Ronald K Binder, Michel A Missinou, Bertrand Lell, Peter G Kremsner
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 50 Issue 5 Pg. 751-4 (Nov 2002) ISSN: 0305-7453 [Print] England
• PMID: 12407136 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Artemisinins
• Sesquiterpenes
• Artesunate

Topics

• Adolescent
• Animals
• Artemisinins (pharmacology, therapeutic use)
• Artesunate
• Child
• Double-Blind Method
• Female
• Humans
• Malaria (blood, drug therapy)
• Male
• Plasmodium malariae (drug effects)
• Sesquiterpenes (pharmacology, therapeutic use)