Abstract | STUDY OBJECTIVES: DESIGN: SETTING: PARTICIPANTS: N/A. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: No antibody test yielded significantly positive results for the group as a whole or for subgroups of patients with cataplexy or positive HLA DQB1*0602 status. CONCLUSIONS: These results do not support the hypothesis that narcolepsy is an autoimmune disease. However, it is possible that the autoimmune attack is very selective and does not involve the epitopes measured in this study. Recent findings that the hypocretin neurotransmission system is involved in animal models of narcolepsy should lead to research to look for antibodies directed against components of the hypocretin neurotransmission system in narcolepsy.
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Authors | John Logan Black 3rd, Lois E Krahn, V Shane Pankratz, Michael Silber |
Journal | Sleep
(Sleep)
Vol. 25
Issue 7
Pg. 719-23
(Nov 01 2002)
ISSN: 0161-8105 [Print] United States |
PMID | 12405606
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQB1 antigen
- Isoenzymes
- Membrane Glycoproteins
- Nerve Tissue Proteins
- Orexin Receptors
- Receptors, G-Protein-Coupled
- Receptors, Neuropeptide
- amphiphysin
- Thyroglobulin
- Glutamate Decarboxylase
- glutamate decarboxylase 2
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Topics |
- Adult
- Antibodies
(immunology)
- Glutamate Decarboxylase
(genetics, immunology)
- HLA-DQ Antigens
(genetics, immunology)
- HLA-DQ beta-Chains
- Humans
- Isoenzymes
(genetics, immunology)
- Membrane Glycoproteins
- Narcolepsy
(genetics, immunology)
- Nerve Tissue Proteins
(genetics, immunology)
- Neurons
(immunology)
- Orexin Receptors
- Point Mutation
(genetics, immunology)
- Receptors, G-Protein-Coupled
- Receptors, Neuropeptide
(genetics, immunology)
- Thyroglobulin
(genetics, immunology)
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