Abstract | BACKGROUND: METHODS: Pigs were subjected to 60 minutes of regional ischemia by reversibly ligating the left anterior descending coronary artery followed by 180 minutes of reperfusion. In the treatment group (n = 6), an FP-15 (1 mg/kg) bolus was infused through the jugular vein after 30 minutes of ischemia followed by a continuous infusion (1 mg x kg(-1) x h(-1)) during reperfusion. Vehicle was infused in the control group (n = 6). Coronary flow was recorded by an ultrasonic flow probe and infarct size determined by tetrazolium staining. Arterial and left ventricular pressures were monitored continuously and regional myocardial function determined by sonomicrometry. RESULTS: No significant differences were observed in either hemodynamics or ischemic area at risk. However, the infarct size was significantly reduced (35.3% +/- 3.5% versus 21.6% +/- 2.6% of the ischemic area, control versus FP-15-treated groups, respectively, p < 0.05). +dP/dt was transiently improved in the FP-15-treated groups while during most of the reperfusion period coronary flow, and was significantly lower in the FP-15-treated group as compared to the control group (p < 0.01). CONCLUSIONS:
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Authors | Cesario Bianchi, Hidetaka Wakiyama, Renato Faro, Tanveer Khan, James D McCully, Sidney Levitsky, Csaba Szabó, Frank W Sellke |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 74
Issue 4
Pg. 1201-7
(Oct 2002)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 12400769
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Animals
- Coronary Circulation
(drug effects)
- Disease Models, Animal
- Female
- Male
- Myocardial Infarction
(pathology)
- Myocardial Reperfusion Injury
(metabolism, physiopathology, prevention & control)
- Peroxynitrous Acid
(metabolism)
- Swine
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