Abstract |
Pathologic T-cell activation is implicated in psoriasis progression. CD80, a costimulatory molecule involved in T-cell activation, likely plays a key role. IDEC-114, an IgG(1) anti-CD80 antibody, was evaluated for safety, pharmacokinetics, and preliminary clinical activity in this open-label, single-dose, dose-escalating study in patients with moderate to severe chronic plaque psoriasis. Twenty-four patients received IDEC-114 (0.05 mg/kg, 0.25 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, or 15 mg/kg). Psoriasis Area and Severity Index, Physician's Global Psoriasis Assessment, and Psoriasis Severity Scale scores improved in the highest-dose groups. Average plaque thickness and plaque CD3+ and CD8+ T-cell counts decreased in the 10 mg/kg dose group. Adverse events were primarily mild, transient, constitutional symptoms; the most common related events were mild asthenia (29% of patients), chills (25%), and headache (21%). The serum half-life of IDEC-114 was approximately 13 days. A single dose of IDEC-114 appears to be safe and well tolerated and has promising clinical activity in psoriasis.
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Authors | Alice B Gottlieb, Mark Lebwohl, Mark C Totoritis, Ahsan A Abdulghani, Steve R Shuey, Patricia Romano, Umesh Chaudhari, Roberta S Allen, Richard G Lizambri |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 47
Issue 5
Pg. 692-700
(Nov 2002)
ISSN: 0190-9622 [Print] United States |
PMID | 12399760
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- galiximab
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
(administration & dosage, pharmacokinetics, therapeutic use)
- Chronic Disease
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Psoriasis
(drug therapy, pathology)
- Severity of Illness Index
- Treatment Outcome
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