Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.

Abstract

BACKGROUND:

The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. In mice, the amount of LRP activity was modulated by RAP, and RAP-null mice showed higher levels of total cholesterol.

OBJECTIVE:

To evaluate the association between DNA polymorphisms at the LRP, LRPAP and alpha2 M genes and early myocardial infarction (MI).

METHODS:

We genotyped 210 patients with early MI (<55 years) and 200 healthy control participants for three polymorphisms in the LRP, LRPAP and alpha2 M genes.

RESULTS:

No association was found between these polymorphisms and plasma lipid levels in patients and control participants. Only the LRPAP-intron 1 polymorphism (a 21 bp insertion/deletion) was associated with MI (P = 0.0065; odds ratio = 2.18, 95% confidence intervals = 1.22-3.90).

CONCLUSIONS:

According to our data, the variation at the LRPAP1 gene could contribute to the risk of developing an early episode of MI.

• Authors: Pelayo González, Ruth Alvarez, Julián R Reguero, Alberto Batalla, Victoria Alvarez, Arturo Cortina, Gustavo I Cubero, Mónica García-Castro, Eliecer Coto
• Journal: Coronary artery disease (Coron Artery Dis) Vol. 13 Issue 5 Pg. 251-4 (Aug 2002) ISSN: 0954-6928 [Print] England
• PMID: 12394648 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 Lippincott Williams & Wilkins

Chemical References

• LDL-Receptor Related Protein-Associated Protein
• LDL-Receptor Related Proteins
• alpha-Macroglobulins

Topics

• Adult
• Humans
• Introns (genetics)
• LDL-Receptor Related Protein-Associated Protein (genetics)
• LDL-Receptor Related Proteins (genetics)
• Male
• Middle Aged
• Myocardial Infarction (genetics)
• Polymorphism, Genetic
• alpha-Macroglobulins (genetics)