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Successful treatment of juvenile myelomonocytic leukemia relapsing after stem cell transplantation using donor lymphocyte infusion.

Abstract
Juvenile myelomonocytic leukemia (JMML) is a rare pediatric malignancy. Hematopoietic stem cell transplantation (SCT) is the only curative approach. However, relapse after SCT remains the major cause of treatment failure. Unlike most other pediatric malignancies, JMML may be susceptible to a graft-versus-leukemia (GVL) effect, although, unlike chronic myeloid leukemia, reports of response to donor lymphocyte infusions (DLIs) remain scanty. This is the first report that describes the successful treatment of relapsed JMML with DLI in the absence of further chemotherapy and provides definite proof of a GVL effect in JMML.
AuthorsAusten Worth, Kanchana Rao, David Webb, Judith Chessells, Jane Passmore, Paul Veys
JournalBlood (Blood) Vol. 101 Issue 5 Pg. 1713-4 (Mar 01 2003) ISSN: 0006-4971 [Print] United States
PMID12393482 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bone Marrow Transplantation
  • Combined Modality Therapy
  • Graft vs Leukemia Effect
  • Humans
  • Immunosuppression Therapy
  • Infant
  • Leukemia, Myelomonocytic, Acute (drug therapy, therapy)
  • Lymphocyte Transfusion
  • Recurrence
  • Remission Induction
  • Salvage Therapy
  • Transplantation Conditioning

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