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Effects of hypocaloric diet on sleep in young and old rats.

Abstract
Aging produces a loss in a number of behavioral and cognitive functions, including sleep. Hypocaloric diet is one of the few methods that have been shown to retard the effects due to age. However, the effects of such a diet on sleep have never been investigated. In the present study, 21 months old male F344 rats fed a 60% calorie-reduced diet continued to have a significant reduction in delta power (0.3-4 Hz EEG), less sleep following 12 h total sleep deprivation (TSD) and increased sensitivity to caffeine compared to young rats (3 months) fed a similar diet. These results indicate that caloric restriction is unable to prevent the decline in sleep that occurs with aging.
AuthorsRafael J Salin-Pascual, Urvashi Upadhyay, Priyattam J Shiromani
JournalNeurobiology of aging (Neurobiol Aging) 2002 Sep-Oct Vol. 23 Issue 5 Pg. 771-6 ISSN: 0197-4580 [Print] United States
PMID12392780 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
CopyrightCopyright 2002 Elsevier Science Inc.
Chemical References
  • Central Nervous System Stimulants
  • Caffeine
Topics
  • Age Factors
  • Animals
  • Body Weight
  • Caffeine (pharmacology)
  • Caloric Restriction
  • Central Nervous System Stimulants (pharmacology)
  • Energy Intake (physiology)
  • Male
  • Rats
  • Rats, Inbred F344
  • Sleep Deprivation (physiopathology)
  • Sleep, REM (drug effects, physiology)
  • Wakefulness (physiology)

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