Abstract | BACKGROUND: OBJECTIVE: METHODS: A retrospective review of anaphylaxis after i.v. phytonadione over a 58-month period at a large academic center was performed. During the period of the study a protocol for the administration of i.v. phytonadione was in place. A review of computerized records and survey of staff identified cases of anaphylaxis meeting predefined inclusion criteria. In addition, a literature review was performed for articles concerning anaphylaxis after i.v. phytonadione. RESULTS: Over the 58 months of the study, a total of 6,572 doses of i.v. phytonadione were administered. Two cases of anaphylaxis after i.v. phytonadione were identified. The incidence of anaphylaxis was 3 per 10,000 doses with 95% confidence intervals of 0.04 to 11 per 10,000 doses. The literature review identified 14 cases meeting inclusion criteria with no reviews of the literature or estimates of incidence. CONCLUSIONS:
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Authors | Douglas L Riegert-Johnson, Gerald W Volcheck |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 89
Issue 4
Pg. 400-6
(Oct 2002)
ISSN: 1081-1206 [Print] United States |
PMID | 12392385
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anaphylaxis
(chemically induced, epidemiology)
- Child
- Female
- Humans
- Incidence
- Injections, Intravenous
- Male
- Middle Aged
- Retrospective Studies
- Vitamin K 1
(adverse effects)
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