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Low levels of nitric oxide and carbon monoxide in alpha 1-antitrypsin deficiency.

Abstract
Quantitations of exhaled nitric oxide (NO) and carbon monoxide (CO) have been proposed as noninvasive markers of airway inflammation. We hypothesized that exhaled CO is increased in individuals with alpha(1)-antitrypsin (AT) deficiency, who have lung inflammation and injury related to oxidative and proteolytic processes. Nineteen individuals with alpha(1)-AT deficiency, 22 healthy controls, and 12 patients with non-alpha(1)-AT-deficient chronic obstructive pulmonary disease (COPD) had NO, CO, CO(2), and O(2) measured in exhaled breath. Individuals with alpha(1)-AT deficiency had lower levels of NO and CO than control or COPD individuals. Alpha(1)-AT-deficient and COPD patients had lower exhaled CO(2) than controls, although only alpha(1)-AT-deficient patients had higher exhaled O(2) than healthy controls. NO was correlated inversely with exhaled O(2) and directly with exhaled CO(2), supporting a role for NO in regulation of gas exchange. Exhaled gases were not significantly related to corticosteroid use or lung function. Demonstration of lower than normal CO and NO levels may be useful as an additional noninvasive method to evaluate alpha(1)-AT deficiency in individuals with a severe, early onset of obstructive lung disease.
AuthorsRoberto F Machado, James K Stoller, Daniel Laskowski, Shuo Zheng, Joseph A Lupica, Raed A Dweik, Serpil C Erzurum
JournalJournal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol (1985)) Vol. 93 Issue 6 Pg. 2038-43 (Dec 2002) ISSN: 8750-7587 [Print] United States
PMID12391056 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Adrenal Cortex Hormones
  • Biomarkers
  • Carbon Dioxide
  • Nitric Oxide
  • Carbon Monoxide
  • Oxygen
Topics
  • Administration, Inhalation
  • Adrenal Cortex Hormones (therapeutic use)
  • Adult
  • Aged
  • Biomarkers
  • Breath Tests
  • Carbon Dioxide (analysis)
  • Carbon Monoxide (analysis)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitric Oxide (analysis)
  • Oxygen (analysis)
  • Pulmonary Disease, Chronic Obstructive (diagnosis, drug therapy, metabolism)
  • alpha 1-Antitrypsin Deficiency (diagnosis, drug therapy, metabolism)

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