The lymphokine eosinophil stimulation promoter and human schistosomiasis mansoni.

Abstract

An in vitro assay for the new lymphokine eosinophil stimulation promoter has been adapted for use with human material. Peripheral eosinophils from patients with schistosomiasis mansoni were specifically induced to migrate on incubation with egg antigen. Furthermore, the peripheral lymphocytes of these patients on incubation with the egg antigen secreted the lymphokine eosinophil stimulation promoter, which enhanced the migration of purified eosinophils from patients with or without schistosomiasis. The test can be easily performed with human target cells and may be helpful for diagnostic or investigative purposes.

• Authors: J W Kazura, A A Mahmoud, K S Karb, K S Warren
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 132 Issue 6 Pg. 702-6 (Dec 1975) ISSN: 0022-1899 [Print] United States
• PMID: 1238460 (Publication Type: Journal Article)

Chemical References

• Antigens
• Lymphokines

Topics

• Antigens
• Cell Movement (drug effects)
• Eosinophils
• Female
• Humans
• Lymphocytes (metabolism)
• Lymphokines (blood, metabolism)
• Ovum (immunology)
• Schistosoma mansoni (immunology)
• Schistosomiasis (blood)