Abstract |
The aim of this study was to evaluate the ability of phenobarbital to block the lung edema observed after intracerebroventricular (icv) injections of tityustoxin (TsTX), a toxic fraction of the Tityus serrulatus venom. We injected 1.74 microg icv (1.0 microl) of TsTX in Wistar rats pre-treated with 0.1 ml intramuscular injections of sterile saline or phenobarbital (60 or 170 mg/kg body weight). After the experiments the lungs were harvested and the pulmonary index (PI = lung/ body weight x 100) calculated. The animals pre-treated with saline developed severe lung edema (PI = 1.8 +/- 0.2) after TsTX icv injection whereas those that received 170 mg/kg of phenobarbital presented no lung edema (PI = 0.71 +/- 0.02). Our results suggest that the lung edema induced by TsTX is of neurogenic nature and that 170 mg/kg of phenobarbital blocks TsTX induced lung edema.
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Authors | Michel Beranos Soares Mesquita, Tasso Moraes-Santos, Márcio Flávio Dutra Moraes |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 332
Issue 2
Pg. 119-22
(Oct 31 2002)
ISSN: 0304-3940 [Print] Ireland |
PMID | 12384225
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2002 Elsevier Science Ireland Ltd. |
Chemical References |
- GABA Modulators
- Neuroprotective Agents
- Scorpion Venoms
- tityustoxin
- Phenobarbital
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Topics |
- Animals
- GABA Modulators
(pharmacology)
- Injections, Intraventricular
- Lung
(pathology)
- Male
- Neuroprotective Agents
- Phenobarbital
(pharmacology)
- Pulmonary Edema
(chemically induced, pathology, prevention & control)
- Rats
- Rats, Wistar
- Respiratory Function Tests
- Scorpion Venoms
(administration & dosage, antagonists & inhibitors, toxicity)
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