Abstract | PURPOSE: DESIGN: Observational study. METHODS: A 31-year-old man presented with bilateral inferior symblepharon, superior tarsal conjunctival scarring and concretions, and recurrent conjunctival and episcleral injection. RESULTS: Four years after initial presentation, the patient developed hepatitis C, and 2 years later blisters on his scalp and hands. Direct immunofluorescence studies of biopsies taken from the palpebral conjunctiva of the right lower lid were negative for cicatricial pemphigoid. A twenty-four hour urine specimen analysis revealed elevated levels of uroporphyrins and polycarboxylated porphyrins, confirming the diagnosis of porphyria cutanea tarda. The patient was treated with repeated phlebotomies and oral hydroxychloroquine, which resulted in a significant decrease in the skin lesions, conjunctival injection, and concretions under the upper lids. CONCLUSIONS:
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Authors | Anna J Park, Guy F Webster, Robert B Penne, Irving M Raber |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 134
Issue 4
Pg. 619-21
(Oct 2002)
ISSN: 0002-9394 [Print] United States |
PMID | 12383830
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Dermatologic Agents
- Porphyrins
- Uroporphyrins
- Hydroxychloroquine
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Topics |
- Administration, Oral
- Adult
- Cicatrix
(complications, pathology)
- Conjunctivitis
(etiology, pathology)
- Dermatologic Agents
(administration & dosage, therapeutic use)
- Humans
- Hydroxychloroquine
(administration & dosage, therapeutic use)
- Male
- Phlebotomy
- Porphyria Cutanea Tarda
(complications, diagnosis, therapy, urine)
- Porphyrins
(urine)
- Skin
(pathology)
- Uroporphyrins
(urine)
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