The emerging role of induced hypothermia in the management of acute stroke.

Abstract

Current treatment of acute stroke remains unsatisfactory. This review presents experimental and clinical data which suggest that mild induced hypothermia could be a potent and practicable neuroprotective treatment of acute ischaemic stroke and intracerebral haemorrhage. Hypothermia, if proven to be safe, effective and widely practicable in patients with acute stroke, could have an enormous positive impact on reducing the burden of stroke worldwide. Critical issues that will need to be considered in a well designed randomised controlled trial of induced hypothermia in acute stroke patients are discussed.

• Authors: Valery L Feigin, Craig S Anderson, Anthony Rodgers, Neil E Anderson, Alistair J Gunn
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 9 Issue 5 Pg. 502-7 (Sep 2002) ISSN: 0967-5868 [Print] Scotland
• PMID: 12383404 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Acute Disease
• Body Temperature (physiology)
• Humans
• Hypothermia, Induced (adverse effects, economics)
• Rewarming
• Shivering (physiology)
• Stroke (epidemiology, therapy)