Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: The study population included 828 patients: 515 who completed the double-blind study, 138 who were discontinued from the double-blind study, and 175 who were enrolled directly. Direct enrollees had poor glycemic control and dyslipidemia at baseline. Improvements in plasma lipid levels were seen as early as week 13. At week 52, the mean change in TC from baseline was -8.0 mg/dL for the total population (95% CI, -10.9 to -5.2; P < 0.05) and -23.2 mg/dL for direct enrollees (95% CI, -30.1 to -16.4; P < 0.05). The mean decrease in LDL-C from baseline for the total population was 2.86 mg/dL (95% CI, -5.3 to -0.4; P < 0.05), compared with a reduction of 13.3 mg/dL for direct enrollees (95% CI, -18.5 to -8.1; P < 0.05). Mean HDL-C levels were minimally affected. Mean TG levels decreased by 27.8 mg/dL for the entire population (95% CI, -42.9 to -12.8; P < 0.05) and by 99.7 mg/dL for direct enrollees (95% CI, -152.5 to -46.8; P < 0.05). CONCLUSION:
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Authors | George E Dailey 3rd, Pharis Mohideen, Fred T Fiedorek |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 24
Issue 9
Pg. 1426-38
(Sep 2002)
ISSN: 0149-2918 [Print] United States |
PMID | 12380634
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Cholesterol, HDL
- Cholesterol, LDL
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Triglycerides
- Metformin
- Glyburide
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Topics |
- Blood Glucose
(analysis)
- Cardiovascular Diseases
(blood, prevention & control)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Drug Therapy, Combination
- Fasting
(blood)
- Female
- Glyburide
(therapeutic use)
- Glycated Hemoglobin
(analysis)
- Humans
- Hyperlipidemias
(drug therapy)
- Hypoglycemic Agents
(therapeutic use)
- Longitudinal Studies
- Male
- Metformin
(therapeutic use)
- Middle Aged
- Risk Factors
- Triglycerides
(blood)
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