Abstract |
The effects of dicloran gel in combination with antibiotics on salivary lipid peroxidation were evaluated in 18 patients aged 23-68 years with chronic generalized rapidly progressing periodontitis. Lipid peroxidation and activity of antioxidant systems surpassed the normal values 2-4-fold in periodontitis patients before treatment. After therapy with metrogil-dent these parameters decreased (p < 0.05). Injection of dicloran gel before antibiotic therapy induced a decrease in these parameters within approximately 30 min. If dicloran gel was injected after metrogil-dent, the maximum decrease in oxidative processes and antioxidant system activity was observed as soon as in 15 min.
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Authors | A I Grudianov, V V Ovchinnikova, L E Serebriakova |
Journal | Stomatologiia
(Stomatologiia (Mosk))
Vol. 81
Issue 4
Pg. 31-4
( 2002)
ISSN: 0039-1735 [Print] Russia (Federation) |
Vernacular Title | Zavisimost' pokazateleĭ perekisnogo okisleniia v sliune ot taktiki lokal'nogo primenenia dikloran-zhele pri parodontite. |
PMID | 12380294
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Aniline Compounds
- Anti-Infective Agents
- Gels
- Metronidazole
- dicloran
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Topics |
- Adult
- Aged
- Aniline Compounds
(administration & dosage)
- Anti-Infective Agents
(administration & dosage)
- Chronic Disease
- Drug Therapy, Combination
- Female
- Gels
- Humans
- Lipid Peroxidation
(drug effects)
- Male
- Metronidazole
(administration & dosage)
- Middle Aged
- Periodontitis
(drug therapy, metabolism)
- Saliva
(drug effects, metabolism)
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