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[Relationship between salivary lipid peroxidation and the strategy of local dichloran gel treatment for periodontitis].

Abstract
The effects of dicloran gel in combination with antibiotics on salivary lipid peroxidation were evaluated in 18 patients aged 23-68 years with chronic generalized rapidly progressing periodontitis. Lipid peroxidation and activity of antioxidant systems surpassed the normal values 2-4-fold in periodontitis patients before treatment. After therapy with metrogil-dent these parameters decreased (p < 0.05). Injection of dicloran gel before antibiotic therapy induced a decrease in these parameters within approximately 30 min. If dicloran gel was injected after metrogil-dent, the maximum decrease in oxidative processes and antioxidant system activity was observed as soon as in 15 min.
AuthorsA I Grudianov, V V Ovchinnikova, L E Serebriakova
JournalStomatologiia (Stomatologiia (Mosk)) Vol. 81 Issue 4 Pg. 31-4 ( 2002) ISSN: 0039-1735 [Print] Russia (Federation)
Vernacular TitleZavisimost' pokazateleĭ perekisnogo okisleniia v sliune ot taktiki lokal'nogo primenenia dikloran-zhele pri parodontite.
PMID12380294 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Aniline Compounds
  • Anti-Infective Agents
  • Gels
  • Metronidazole
  • dicloran
Topics
  • Adult
  • Aged
  • Aniline Compounds (administration & dosage)
  • Anti-Infective Agents (administration & dosage)
  • Chronic Disease
  • Drug Therapy, Combination
  • Female
  • Gels
  • Humans
  • Lipid Peroxidation (drug effects)
  • Male
  • Metronidazole (administration & dosage)
  • Middle Aged
  • Periodontitis (drug therapy, metabolism)
  • Saliva (drug effects, metabolism)

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