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Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function.

Abstract
The root of Panax ginseng C. A. Meyer is one of the most popular natural tonics in oriental countries. In this study, we have isolated polysaccharide fraction of Panax ginseng (ginsan) and examined its effect on the function of murine peritoneal macrophages. When macrophages were treated with ginsan, cytotoxic activity against B16 melanoma cells was significantly induced. In addition, the levels of cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and Interferon-gamma (IFN-gamma) were increased and the production of reactive oxygen/nitrogen components such as nitric oxide (NO) and hydrogen peroxide (H2O2) was enhanced. Moreover, phagocytic activity was induced in ginsan-treated macrophages compared to the control. The expression of CD14 and 1-Ab on murine peritoneal macrophages was increased by the treatment with ginsan, while the expression of CD11b was decreased. Taken together, these results suggest that ginsan has an immunopotentiating effects on macrophages and these abilities could be used clinically for the treatment of diseases such as cancer.
AuthorsJae-Yong Shin, Ji-Young Song, Yeon-Sook Yun, Hyun-Ok Yang, Dong-Kwon Rhee, Suhkneung Pyo
JournalImmunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 24 Issue 3 Pg. 469-82 (Aug 2002) ISSN: 0892-3973 [Print] England
PMID12375741 (Publication Type: Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • CD11b Antigen
  • Cytokines
  • Histocompatibility Antigens Class II
  • Lipopolysaccharide Receptors
  • Plant Extracts
  • Polysaccharides
  • ginsan
  • Nitric Oxide
  • Hydrogen Peroxide
Topics
  • Adjuvants, Immunologic (pharmacology)
  • Animals
  • CD11b Antigen (analysis)
  • Cytokines (biosynthesis)
  • Histocompatibility Antigens Class II (analysis)
  • Hydrogen Peroxide (metabolism)
  • Lipopolysaccharide Receptors (analysis)
  • Macrophages (drug effects, physiology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nitric Oxide (biosynthesis)
  • Panax
  • Phagocytosis (drug effects)
  • Plant Extracts (pharmacology)
  • Plant Roots
  • Polysaccharides (pharmacology)

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